于抗抗
365英国上市网站官网, 365英国上市网站官网, 副研究员，kangkangyu@scu.edu.cn。
目前的研究工作主要以干细胞衰老、精子病因学诊断为导向，设计合成荧光分子探针，以之为工具辅助解决临床问题。设计、合成了一系列荧光探针，实现了活细胞内活性氧（ROS），线粒体基因组中的G-四链体（mtG4），细胞内微环境（pH、粘度），某些活细胞中特异性表达的酶（如β-半乳糖苷酶、硝基还原酶、单胺氧化酶）等的快速、高效的识别，并以这些探针为工具，进一步实现了上述活性物质在干细胞衰老及精子病变过程中的快速、高选择及定量检测。其中，基于开发的具有线粒体靶向的近红外G四链体（mtG4）荧光探针，不但发现衰老干细胞中mtG4的异常升高，而且检测出临床不育精子中的mtG4也显著升高，并进一步研究了mtG4调控的线粒体功能障碍，为延缓干细胞衰老及提升精子活性，提供了可行的方案。此外，新开发的窄pH及β-Gal/次氯酸双响应探针有望为临床上原因不明得男性不育患者，提供可供检测的精子病因学新指标。目前，以第一作者及通讯作者在Aging Cell, ACS Sensors, Sensor. Actuator. B-Chem., Chem等杂志上发表论文20余篇，获准国家发明专利4项。
教育与工作经历：
(1) 2013-07 至 2018-06, 365英国上市网站官网, 有机化学, 博士
(2) 2016-09 至 2017-12, 芝加哥大学, 表观遗传学, 联合培养博士
(3) 2009-09 至 2013-06, 365英国上市网站官网, 化学类, 学士
(4) 2018-07 至 2020-04, 365英国上市网站官网，365英国上市网站官网，助理研究员
(5) 2020-05 至 今, 365英国上市网站官网, 365英国上市网站官网, 副研究员
科研项目：
(1) 国家自然科学基金委员会, 青年科学基金项目, 22107078, 靶向mtG4的新型荧光探针的构建及其在阐释mtG4在MSCs衰老中调控机制的应用初探, 2022-01-01 至 2024-12-31，主持
(2) 浙江省检验诊断及转化研究重点实验室, 浙江省检验诊断及转化研究重点实验室开放基金，2022E10022-2023-2, 干细胞衰老过程中的G4荧光成像研究, 2024-01 至 2025-12，主持
(3) 广东省口腔医学重点实验室, 广东省口腔医学重点实验室开放课题基金, KF2020120101 , 可注射智能水凝胶缓释牙囊干细胞外泌体促进炎症牙髓修复的研究, 2021-01 至 2022-12, 主持
(4) 国家自然科学基金委员会, 面上项目, 32071275, 铁代谢关键蛋白O-GlcNAc糖基化修饰变化在肿瘤细胞铁死亡调控中的作用机制研究, 2021-01-01 至 2024-12-31, 参与
(5) 国家自然科学基金委员会, 面上项目, 81970925, 牙囊干细胞外泌体传递效应miRNA调控牙髓炎免疫的机制及智能递释体系的构建, 2020-01-01 至 2023-12-31，参与
近五年论文发表（#,共同第一作者；*,通讯作者）：
(1)Kang-Kang Yu, Kun Li,* Hao-Yuan Wang, Xiao-Liang Li, Si-Xian Wu, Wen-Ming Xu,* Yan-Hong Liu, Chuan-Fang Wu, Xiao-Qi Yu, Jin-Ku Bao* Construction of Near-Infrared Probes with Remarkable Large Stokes Shift Based on a Novel Purine Platform for the Visualization of mtG Upregulation during Mitochondrial Disorder in Somatic Cells and Human Sperms. Anal. Chem., 2024, 96, 11915-11922.
(2)Kang-Kang Yu,# Fei-Fei Li#, Ling Ye*, Fan-Yuan Yu* Accumulation of DNA G-quadruplex in Mitochondrial Genome Hallmarks Mesenchymal Senescence. Aging Cell, 2024; 00, e14265.
(3)Yi-Min Shan, Kang-Kang Yu,* Fan-Yuan Yu, Yan-Hong Liu, Xiao-Qi Yu, Kun Li Ultrasensitive Two-photon Probes for Rapid Detection of β-galactosidase During Fruit Softening and Cellular Senescence. Food Chem., 2024, 431, 137117.
(4)Meng-Jie Li,# Jun Tian,# Kang-Kang Yu,# He Liu, Xiao-Qi Yu, Nan Wang, Qi-Mei Gong,* Kun Li,*, Ya Shen,*, Xi Wei* A ROS-responsive Hydrogel Incorporated with Dental Follicle Stem Cell-derived Small Extracellular Vesicles Promotes Dental Pulp Repair by Ameliorating Oxidative Stress. Bioact. Mater., 2024, 36, 524-540.
(5)Si-Xian Wu, Xiao-Liang Li, Ge-Lin Huang, Jun-Cen Guo, Xue-Guang Zhang, Lu Liao, Wei-Wei Zhi, Kun Li, Yan Wang, Zhi-Wen Chu, Li-Jun Shang, Xiao-Qi Yu, Kang-Kang Yu,* Wen-Ming Xu* Dissecting Sperm Mitochondrial G-Quadruplex Structures Using a Fluorescent Probe Biomarker to Monitor and Regulate Fertilization Capability. ACS Sens., 2023, 8, 2186-2196.
(6)Yi-Min Shan, Li-Na Zhang, Si-Xian Wu, Xiao-Liang Li, Hong Zhang, Fei-Fan Xiang, Fan-Yuan Yu, Yan-Hong Liu, Xiao-Qi Yu, Kun Li, Wen-Ming Xu, Kang-Kang Yu* Revelation of β-galactosidase Variation in Senile Sperms and Organs via a Silicon Xanthene Near-infrared Probe. Sensor. Actuator. B-Chem., 2023, 397, 134663.
(7)Nan Wang, Kang-Kang Yu,* Kun Li, Xiao-Qi Yu* A Novel Triple-network Hydrogel based on Borate Ester Groups: from Structural Modulation to Rapid Wound Hemostasis. J. Mater. Chem. B, 2023, 11, 1232.
(8)Nan Wang, Kang-Kang Yu,* Kun Li, Xiao-Qi A Biocompatible Polyethylene Glycol/alginate Composite Hydrogel with Significant Reactive Oxygen Species Consumption for Promoting Wound Healing. J. Mater. Chem. B, 2023, 11, 6934.
(9)Yi-Min Shan , Kang-Kang Yu,* Nan Wang, Fan-Yuan Yu, Kun Li, Yan-Hong Liu, Xiao-Qi Yu* Assessing ClO- During ER Stress and Cellular Senescence Through a Ratio Fluorescent Probe with Ddual Organelle Targeting Ability Sensor. Actuator. B-Chem., 2022, 358, 131383.
(10) Kang-Kang Yu,# Sheng-Lin Pan,# Kun Li, Lei Shi, Yan-Hong Liu, Shan-Yong Chen*, Xiao-Qi Yu* A Novel Near-Infrared Fluorescent Sensor for Zero Background Nitrite Detection via the “Covalent-assembly” Principle. Food Chem., 2021, 341, 128254.
(11) Hao-Yuan Wang, Kang-Kang Yu,* Chong-Yun Tan, Kun Li, Yan-Hong Liu, Lei Shi, Kai Lu, Xiao-Qi Yu* Three-in-one: Information Encryption, Anti-counterfeiting and LD-tracking of Multifunctional Purine Derivatives. J. Mater. Chem. C, 2021, 9, 2864-2872.
(12) Nan Wang, Kang-Kang Yu,* Kun Li, Meng-Jie Li, Xi Wei,* Xiao-Qi Yu* Plant-Inspired Multifunctional Fluorescent Hydrogel: A Highly Stretchable and Recoverable Self-Healing Platform with Water-Controlled Adhesiveness for Highly Effective Antibacterial Application and Data Encryption Decryption. ACS Appl. Mater. Interfaces, 2021, 12, 57686.
(13) Hao-Yuan Wang, Chong-Yun Tan, Kang-Kang Yu,* Kun Li, Yan-Hong Liu, Xiao-Qi Yu* Multifunctional Lipophilic Purines: a Coping Strategy for Anti-counterfeiting Lipid Droplet Imaging and Latent Fingerprint Development. Mater. Chem. Front., 2021, 5, 6603.
(14) Shan Wang,* Bing-Ya Wang, Lei Zhu, Ji-Ting Hou,* Kang-Kang Yu* A Ratiometric Fluorescent Probe for Monitoring pH Fluctuations During Autophagy in Living Cells. Chem. Commun., 2021, 57, 1510-1513.
(15) Kang-Kang Yu, Kun Li, Hui-Zi He, Yan-Hong Liu, Jin-Ku Bao,* Xiao-Qi Yu* A Label-free Fluorescent Probe for Accurate Mitochondrial G-quadruplex Structures Tracking via Assembly Hindered Rotation Iinduced Emission. Sensor. Actuator. B-Chem., 2020, 321, 128479.
(16) Kang-Kang Yu, Kun Li, Chun-Yan Lu, Yong-Mei Xie, Yan-Hong Liu, Qian Zhou, Jin-Ku Bao*, Xiao-Qi Yu* Multifunctional Gold Nanoparticles as Smart Nanovehicles with Eenhanced Ttumour-targeting Abilities for Intracellular pH Mapping and in vivo MR/Fluorescence Imaging. Nanoscale, 2020, 12, 2002-2010.
(17) Ji-Ting Hou,# Kang-Kang Yu,# Kyoung Sunwoo,# Won Young Kim, Seyoung Koo, Jinyu Wang, Wen Xiu Ren, Shan Wang,* Xiao-Qi Yu,* Jong Seung Kim* Fluorescent Imaging of Reactive Oxygen and Nitrogen Species Associated with Pathophysiological Processes. Chem, 2020, 6, 1-35.
授权专利：
一种基于嘌呤骨架的近红外发射荧光分子及其制备方法和应用，中国, 202310213757.8
一种精子中线粒体 DNA G-四聚体在男性不育症中的应用和产品, 中国, 202310155039.X
一种化合物RCPH及其合成方法、作为比率型pH探针的应用和产品，中国，ZLCN202410546205.3
基于香豆素骨架的抗菌水凝胶及其制备方法和应用，中国， CN202010290097.X
